生物信息学实习.docVIP

实习 一 ： 序列查询 实验目的： 了解三大生物信息中心的资源； 学会用Entre系统查找目标序列； 学会用SRS系统查找目标序列 实验内容： 三大生物信息中心浏览 NCBI、EBI、DDBJ （二） Entrez的使用 Limits and Advanced Search (三) SRS的使用 作业： 1. Introduce the following NCBI databases in your own words：MMDB，CDD，dbGap, PMC.，OMIM, UniGene, PubChem, RefSeq. 1).MMDB: Structure (Molecular Modeling Database ) is Three dimensional structure which provide a wealth of information on the biological function and the evolutionary history of macromolecules. 2).CDD: Conserved Domain Database (CDD) is a protein annotation resource that consists of a collection of well-annotated multiple sequence alignment models for ancient domains and full-length proteins. 3).dbGap: The database of Genotypes and Phenotypes(dbGaP) is developed to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype. 4).PMC: PubMed Central (PMC) is a free archive of biomedical and life sciences journal literature to keep with NLM’s legislative mandate to collect and preserve the biomedical literature. 5).OMIM: Online Mendelian Inheritance in Man(OMIM) is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. 6).UniGene: UniGene is a database that computationally identifies transcripts from the same locus; analyzes expression by tissue, age, and health status; and reports related proteins(protEST) and clone resources. 7).Pubchem：PubChem is a chemical module database that provides information on the biological activities of small molecules which includes substance information,?compound structures, and BioActivity data in three primary databases, Pcsubstance, Pccompound, and PCBioAssay, respectively 8).RefSeq: The Reference Sequence (RefSeq)is a collection which aims to provide a comprehensive, integrated, non-redundant, well-annotated set of sequences, including genomic DNA, transcripts, and proteins. 2. Make a list of the molecular biology related books on the NCBI bookshelf, specifying the book