糖基化終產物致糖尿病認知障礙BDNF-TrkB-CREB信號介導的海馬重.doc

糖基化终产物致糖尿病认知障碍：BDNF-TrkB-CREB信号介导的海马重塑神经网络机制研究 Advanced glycation end products induced diabetic cognitive impairment: Neural network mechanisms of hippocampal BDNF-TrkB-CREB signal mediated remodeling 单位：东南大学附属医院内分泌科 资金来源：国家自然科学基金面上项目 SB版本日期：2013年2月28日 项目负责人：王少华教授 Hospital: Affiliated Hospital of Southeast University, of Endocrinology Funding: National Natural Science Foundation of China SBDate: February 28, 2013 本文件所包含的所有信息均应视为机密，同时东南大学附属中大医院对此保留独家所有权。这些信息的使用必须限于方案规定的目的，不论是何原因、以何形式，未事先得到东南大学附属中大医院内分泌科的书面同意，禁止披露、发表或与其他非授权人交流。 All the information contained in this document should be regarded as confidential, and affiliated zhongda hospitalof southeast university to retain sole ownership. The purpose of the use of these information must be limited to plan provisions, whatever the reason, in any form, did not obtain prior written consent of southeast university affiliated zhongda hospital endocrinology, prohibited to disclose, publish or communicate with any other unauthorized person.  目 录 Contents 1.研究背景 Background 2.研究设计 Study Design 3.可行性分析 Feasibility Analysis 4.不良事件 Adverse events 5.严重不良事件 Serious adverse events 6.研究者速报事件 Researchers quick - reporting event 7.伦理和法规 Ethics and regulations 8.研究监查 Study Monitoring 9.管理细则 Management rules 1、研究背景 Background 全球目前大约17.1亿糖尿病人，预计到2030年将会是36.6亿。中国糖尿病患病率高达11.6%，糖尿病前期患病率高达50.1%，约有1.57亿糖尿病人，而糖尿病前期约有6.9亿。大脑不仅极度依赖葡萄糖供能，而且同肾脏、心脏、视网膜一样，是糖尿病易累及器官。糖尿病可以造成一过性和永久性认知障碍。据临床学数据表明，糖尿病认知障碍患病率在糖尿病人群众为60%~70%。随着糖尿病发病率的增高、发病的年轻化，都预示着糖尿病相关并发症的增加，而糖尿病认知障碍的存在极大得损伤了患者的工作、学习、生活能力，给家庭和社会造成巨大负担。糖尿病可通过多种途径影响认知功能，包括高血糖、血脂异常、胰岛素缺乏、糖毒性及加速的A(沉积，胰岛素生长因子IGF-1缺乏，GSK3(基因缺陷，IDE，CETP, ABCA1，CLU，PS，CLUSTERIN，CYSTATIN基因突变及异常表达，但潜在的相关机制目前仍不清楚。 Currently, there are about 1.71 billion people with type 2 diabetes mellitus all over the world, it is expected to be 3.66 billion in 2030. The prevalence rate of diabetes in China is 11.6%, and the rate of pre-diabetes prevalence is 50.1%, there are about 157 million people with diabetes in C