右旋美托嘧啶的临床应用综述.docVIP

右旋美托嘧啶的临床应用进展 摘要：右旋美托嘧啶是强效和高选择性(2受体激动剂，具有抗交感神经兴奋、镇静、遗忘、镇痛和心脑肾器官保护等作用。与另一(2受体激动剂（可乐定）比较，右旋美托嘧啶的半衰期更短，对(2受体的选择性更高以及亲和力更强。在临床应用上，右旋美托嘧啶呼吸抑制作用轻微、血流动力学稳定，并可减少阿片类药物的剂量。基于上述优点，目前右旋美托嘧啶已广泛用于术前镇静、各类手术麻醉、术后镇痛和ICU镇静等领域。本文就右旋美托嘧啶的药理学和临床应用予以综述Progress of dexmedetomidine in clinical application Abstract: Dexmedetomidine is a (2 adrenoreceptor agonist with potent effect and high selectivity. Dexmedetomidine has sympatholytic, sedative, amnestic, analgesic, and organ (heart, brain and kedney) protection properties.Compared with clonidine, Dexmedetomidine has shorter half-life, more highly selective and affini