Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome.pdfVIP

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Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome.pdf

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Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome

n engl j med 356;6 february 8, 2007 551 The new england journal of medicine established in 1812 february 8, 2007 vol. 356 no. 6 Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome Richard S. Legro, M.D., Huiman X. Barnhart, Ph.D., William D. Schlaff, M.D., Bruce R. Carr, M.D., Michael P. Diamond, M.D., Sandra A. Carson, M.D., Michael P. Steinkampf, M.D., Christos Coutifaris, M.D., Ph.D., Peter G. McGovern, M.D., Nicholas A. Cataldo, M.D., Gabriella G. Gosman, M.D., John E. Nestler, M.D., Linda C. Giudice, M.D., Ph.D., Phyllis C. Leppert, M.D., Ph.D., and Evan R. Myers, M.D., M.P.H., for the Cooperative Multicenter Reproductive Medicine Network* A bs tr ac t From Pennsylvania State University Col- lege of Medicine, Hershey (R.S.L.); Duke University Medical Center, Durham, NC (H.X.B., E.R.M.); University of Colorado, Denver (W.D.S.); University of Texas South- western Medical Center, Dallas (B.R.C.); Wayne State University, Detroit (M.P.D.); Baylor College of Medicine, Houston (S.A.C.); University of Alabama, Birming- ham (M.P.S.); University of Pennsylvania School of Medicine, Philadelphia (C.C.); University of Medicine and Dentistry of New Jersey, Newark (P.G.M.); Stanford University, Stanford, CA (N.A.C.); Univer- sity of Pittsburgh, Pittsburgh (G.G.G.); Virginia Commonwealth University School of Medicine, Richmond (J.E.N.); Univer- sity of California at San Francisco, San Francisco (L.C.G.); and the National In- stitute of Child Health and Human De- velopment, Bethesda, MD (P.C.L.). Ad- dress reprint requests to Dr. Legro at the Department of Obstetrics and Gynecolo- gy, Pennsylvania State University College of Medicine, M.S. Hershey Medical Cen- ter, 500 University Dr., H103, Hershey, PA 17033, or at rsl1@. *Other members of the Cooperative Mul- ticenter Reproductive Medicine Network are listed in the Appendix. N Engl J Med 2007;356:551-66. Copyright ? 2007 Massachusetts Medical Society. Background The poly