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Gradual Translocation of Spatial Correlates of Neuronal Firing in the Hippocampus toward Pr.pdf

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Gradual Translocation of Spatial Correlates of Neuronal Firing in the Hippocampus toward Pr

Neuron 51, 639–650, September 7, 2006 a2006 Elsevier Inc. DOI 10.1016/j.neuron.2006.06.033Gradual Translocation of Spatial Correlates of Neuronal Firing in the Hippocampus toward Prospective Reward LocationsInah Lee,1,2,* Amy L. Griffin,1 Eric A. Zilli,1 Howard Eichenbaum,1 and Michael E. Hasselmo1,* 1Center for Memory and Brain Boston University 2 Cummington Street Boston, Massachusetts 02215 Summary In a continuous T-maze alternation task, CA1 complex- spike neurons in the hippocampus differentially fire as the rat traverses overlapping segments of the maze (i.e., the stem) repeatedly via alternate routes. The temporal dynamics of this phenomenon were further investigated in the current study. Rats learned the alternation task from the first day of acquisition and the differential firing pattern in the stem was observed accordingly. More importantly, we report a phenome- non in which spatial correlates of CA1 neuronal en- sembles gradually changed from their original firing locations, shifting toward prospective goal locations in the continuous T-maze alternation task. The relative locations of simultaneously recorded firing fields, however, were preserved within the ensemble spatial representation during this shifting. The within-session shifts in preferred firing locations in the absence of any changes in the environment suggest that certain cognitive factors can significantly alter the location- bound coding scheme of hippocampal neurons. Introduction The role of the hippocampal memory system in remem- bering discrete episodic events in a particular environ- ment is well-recognized (Eichenbaum, 2000; McClel- land, 1998; O’Keefe and Nadel, 1978; Vargha-Kadem et al., 1997). It has been proposed that the spatial infor- mation of events is represented by complex-spike neu- rons (‘‘place cells’’) in the hippocampus since they ex- hibit strong firing correlates with particular locations (‘‘place field;’’ O’Keefe and Dostrovsky, 1971). However, it is largely unknown h