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Synthesis, anti-bacterial and anti-fungal activities of some.pdf

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Synthesis, anti-bacterial and anti-fungal activities of some

lable at ScienceDirect European Journal of Medicinal Chemistry 45 (2010) 651–660Contents lists avaiEuropean Journal of Medicinal Chemistry journal homepage: ht tp: / /www.elsevier .com/locate /e jmechOriginal article Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring S.K. Bharti a, G. Nath b, R. Tilak b, S.K. Singh a,* aDepartment of Pharmaceutics, Institute of Technology, Banaras Hindu University (BHU), Varanasi-221005, India bDepartment of Microbiology, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi-221005, Indiaa r t i c l e i n f o Article history: Received 4 June 2009 Received in revised form 19 August 2009 Accepted 2 November 2009 Available online 6 November 2009 Keywords: Schiff bases 2,4-Disubstituted thiazoles Anti-bacterial Anti-fungal Thiosemicarbazone* Corresponding author. Tel.: t91 5426702736; fax E-mail address: sksingh.phe@itbhu.ac.in (S.K. Sing 0223-5234/$ – see front matter 2009 Elsevier Mas doi:10.1016/j.ejmech.2009.11.008a b s t r a c t A series of arylidene-2-(4-(4-methoxy/bromophenyl) thiazol-2-yl) hydrazines (4a–z) and 1-(4-(4- methoxy/bromophenyl) thiazol-2-yl)-2-cyclohexylidene/cyclopentylidene hydrazines (5a–b/6a–b) were synthesized, characterized and screened for their antimicrobial activities. The structures of synthesized compounds were established by spectroscopic (FT-IR, 1H NMR, 13C NMR, Mass) and elemental analyses. Both the anti-bacterial and anti-fungal activities with MIC values of compounds were evaluated. The results of anti-bacterial screening reveal that among all the compounds screened eight compounds showed moderate to good anti-bacterial activity while ten of the newly synthesized compounds dis- played good to excellent anti-fungal activity. Among the tested compounds, the most effective compounds with MIC value in the range of 6.25–25 mg/ml are 4a, 4n, 4z, 5a, 5b, 6a and 6b against three fungal strains viz. Candida albicans, C