NF-κB信号通路与细胞衰老.pdf

邓韵婷 , 等 . NF-κB信号通路与细胞衰老 · 401 · 收稿日期：2012-12-04 基金项目：国家自然科学基金项目3097162081170327)；广东省自然科学基金项目(S2012010008219；9252402301000002； S2011010002922）；广东省医学科研基金项目(B2009191；A2011431；A2012420)；东莞市科技计划医疗卫生类重点项目 (2011105102007)；广东医学院科技创新基金项目(STIF201102) 第一作者：邓韵婷(1987-)，女，硕士生，E-mail: yuntingdeng@ *通信作者：刘新光(1964-)，男，博士，教授， E-mail: xgliu64@126.com 生命的化学 , 2013, 33(4): 401-406 NF-κB信号通路与细胞衰老 邓韵婷1,2，熊兴东1,2,3，孙雪荣1,2，刘新光1,2,3* (1广东省医学分子诊断重点实验室，东莞 523808；2广东医学院衰老研究所，东莞 523808； 3广东医学院生物化学与分子生物学研究所，湛江 524023) 摘要：生物体衰老是一个非常复杂的过程，目前其发生发展机制还不明了。研究发现核因子 κB(nuclear factor-κB, NF-κB)信号通路对于细胞衰老的调节具有重要的作用，这对于认识衰老的发生 发展有重要意义。本文综述了近年来关于NF-κB信号通路与细胞衰老的相关研究，主要内容包括： NF-κB信号通路的分子机制；NF-κB信号通路与细胞衰老的关系；能量限制研究与NF-κB信号通路； NF-κB信号通路与其他衰老相关通路的联系；NF-κB信号通路与老年性疾病的研究。深入探讨NF-κB 信号通路在细胞衰老中的作用，可为阐明衰老的分子机制、延缓衰老和防治衰老相关疾病提供新的思 路。 关键词：NF-κB；信号通路；细胞衰老；老年性疾病 NF-κB pathway and cellular senescence DENG Yunting1,2, XIONG Xingdong1,2,3, SUN Xuerong1,2, LIU Xinguang1,2,3* (1Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan 523808, China; 2Institute of Aging Research, Guangdong Medical College, Dongguan 523808, China; 3Institute of Biochemistry Molecular Biology, Guangdong Medical College, Zhanjiang 524023, China) Abstract: The aging of the organism is a very complex process, and the mechanisms of its occurrence and development is not known. Studies have showed that NF-κB pathway plays important roles in the regulation of cellular senescence, which has great significance for the understanding of the occurrence of aging. This review focuses on the recent advances on the role of the NF-κB pathway in cellular senescence. The main contents of this review include the followings: molecular mechanisms of the NF-κB pathway, NF-κB pathway and cellular senescence, caloric restriction and NF-κB pathway, the relationship between NF-κB pathway and other aging-related pathways, and NF-κB pathway in age-associated diseases. E