Cancer Stem Cells Successful therapy must eradicate cancer stem cells.pdfVIP

DOI: 10.1634/stemcells.2006-0136 published online Aug 24, 2006; Stem Cells David Dingli and Franziska Michor Successful therapy must eradicate cancer stem cells This information is current as of April 14, 2008 http://www.StemC the World Wide Web at: The online version of this article, along with updated information and services, is located on 1549-4918. Carolina, 27701. ? 2006 by AlphaMed Press, all rights reserved. Print ISSN: 1066-5099. Online ISSN: Northowned, published, and trademarked by AlphaMed Press, 318 Blackwell Street, Suite 260, Durham, STEM CELLS? is a monthly publication, it has been published continuously since 1983. The Journal is and genomics; translational and clinical research; technology development. embryonic stem cells; tissue-specific stem cells; cancer stem cells; the stem cell niche; stem cell genetics STEM CELLS?, an international peer-reviewed journal, covers all aspects of stem cell research: b y o n A p r i l 1 4 , 2 0 0 8 w w w .S t e m C e l l s .c o m D o w n l o a d e d f r o m 1 Cancer Stem Cells Successful therapy must eradicate cancer stem cells David Dingli 1,2 and Franziska Michor 1,3 1 Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138 2 Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905 3 Society of Fellows, Harvard University, Cambridge, MA 02138 Correspondence: David Dingli Program for Evolutionary Dynamics Harvard University One Brattle Square, Suite 6 Cambridge, MA 02138 Telephone: 617 496 5543 Fax: 617 496 4629 Email: dingli.david@ Running title: Cancer stem cell therapy Word Count Abstract: 129 Main text: 3075 Keywords: Hematopoiesis, cancer, stem cell, mathematical modeling, therapy Received on March 8, 2006; accepted for publication on August 16, 2006. ? AlphaMed Press 1066-5099 doi: 10.1634/stemcells.2006-0136 Stem Cells Express, published online August 24, 2006; doi:10.1634/stemcells.20