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Chemically modified light-curable chitosans with enhanced
Chemically modified light-curable chitosans with enhanced
potential for bone tissue repair
Yongzhi Qiu,1 Ning Zhang,1,2 Qian Kang,3 Yuehuei An,3 Xuejun Wen1–3
1Clemson-MUSC Bioengineering Program, Department of Bioengineering, Clemson University, Charleston,
South Carolina 29425
2Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425
3Department of Orthopedic Surgery, Medical University of South Carolina, Charleston, South Carolina 29425
Received 9 September 2007; revised 12 December 2007; accepted 8 February 2008
Published online 8 May 2008 in Wiley InterScience (). DOI: 10.1002/jbm.a.32017
Abstract: Light curable polymers are showing great
potential in overcoming some of the current obstacles in
bone repair. With stereolithography, they can be fabricated
into scaffolds with desired topography for repairing bone
defects in irregular shapes. In this study, we developed a
series of light curable chitosans, which have photocurabil-
ity and good solubility in organic solvent. Through adjust-
ing the feeding ratio of the raw components, the content of
photocurable groups in the backbone of chitosan can be
controlled. The light curable chitosans were characterized
through FTIR–ATR and 1H NMR, which also confirmed
their controllable photocurability. NIH 3T3 fibroblasts
were co-cultured with the photocured samples for 7 days
and the results indicated that these photocured chitosans
are cyto-compatible. Scaffolds with interconnected pores,
fabricated using salt leaching and photocuring and seeded
with fetal bovine osteoblasts, were implanted subcutane-
ously in the backs of athymic rat. Histological study on the
implants at 6 weeks showed that the photocured chitosans
have good osteoconductivity. The results indicated the
light curable chitosans have good biocompatibility and
osteoconductivity. 2008 Wiley Periodicals, Inc. J Biomed
Mater Res 89A: 772–779, 2009
Key words: light curable; chitosan; osteoconductivity; bo
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