Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill.pdf

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Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill.pdf

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Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill

Available online /content/13/4/R132Open AccessVol 13 No 4Research Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill, long-term acute female patients: a prospective observational cohort study Rob JM Strack van Schijndel1, Peter JM Weijs2, Rixt H Koopmans1, Hans P Sauerwein3, Albertus Beishuizen1 and Armand RJ Girbes1 1Department of Intensive Care Medicine, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, the Netherlands 2Department of Nutrition and Dietetics, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, the Netherlands 3Palmgracht 44 B, 1015 HN Amsterdam, the Netherlands Corresponding author: Peter JM Weijs, p.weijs@vumc.nl Received: 16 Mar 2009 Revisions requested: 27 Apr 2009 Revisions received: 9 Jul 2009 Accepted: 11 Aug 2009 Published: 11 Aug 2009 Critical Care 2009, 13:R132 (doi:10.1186/cc7993) This article is online at: /content/13/4/R132 ? 2009 Strack van Schijndel et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Optimal nutrition for intensive care patients has been proposed to be the provision of energy as determined by indirect calorimetry, and protein provision of at least 1.2 g/kg pre-admission weight per day. The evidence supporting these nutritional goals is based on surrogate outcomes and is not yet substantiated by patient oriented, clinically meaningful endpoints. In the present study we evaluated the effects of achieving optimal nutrition in ICU patients during their period of mechanical ventilation on mortality. Methods This was a prospective observational cohort study in a mixed medical-surgical, 28-bed ICU in an academic hospital. 243 sequential mixed medical-surgical patients were enrolled on day 3–5 after ad