DNA编码化合物库应用与新药发现的效率分析-roche.pdf

This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication. Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available. You can find more information about Accepted Manuscripts in the Information for Authors. Please note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal’s standard Terms Conditions and the Ethical guidelines still apply. In no event shall the Royal Society of Chemistry be held responsible for any errors or omissions in this Accepted Manuscript or any consequences arising from the use of any information it contains. Accepted Manuscript MedChemComm /medchemcomm View Article Online View Journal This article can be cited before page numbers have been issued, to do this please use: O. Eidam and A. Satz, Med. Chem. Commun., 2016, DOI: 10.1039/C6MD00221H. 1 Analysis of the Productivity of DNA Encoded Libraries? Keywords: DNA encoded, combinatorial chemistry, combinatorial libraries, encoded library, library screening, DEL, hit ID, DNA conjugates. Oliv Eidam and Alexander L. Satz Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland. Email: Alexander_lee.satz@ ?The authors declare no competing interests. Abstract DNA encoded library screens have gained recent interest as they allow for screening of millions of small molecules in a simple manner, with the goal of providing novel chemical starting points in target-based hit identification. Despite t