Photodegradation studies on Atenolol by liquid chromatography.pdfVIP

Journal of Pharmaceutical and Biomedical Analysis 21 (1999) 851–857 Photodegradation studies on Atenolol by liquid chromatography V. Andrisano, R. Gotti, A. Leoni, V. Cavrini * Dipartimento di Scienze Farmaceutiche, Uni6ersita? di Bologna, Via Belmeloro 6, 40126 Bologna, Italy Received 22 April 1999; received in revised form 21 July 1999; accepted 26 July 1999 Abstract The photostability of the b-blocker drug Atenolol was evaluated at pH 9, 7.4 and 4.0. The drug was exposed to UVA–UVB radiations and the photoproducts were detected by reversed phase LC methods. The photodegradation was found to