黄酮类化合物和脑健康幻灯片.pptVIP

* * * * * * * * * * * * * * * * Changes in Hippocampal ERK1/2 pERK 44 pERK 42 Y Y O B O B ERK2 pERK 44 pERK 42 a *** b ** Relative Band Intensity pERK/ERK 0.0 0.5 1.0 1.5 2.0 Aged Young Aged + BB a/b = p ? 0.001 *** = p ? 0.001 ** = p ? 0.01 ERK PKC CREB PKA CaMK Hippocampal changes in Akt pAkt (Ser 473) Akt PKA C CaMKIV (Thr 196) CaMKIV Y Y O B O B pAkt (Ser 473) CaMKIV (Thr 196) PKA (Thr 197) *** b Relative Band Intensity 0.0 0.5 1.0 1.5 2.0 a a Aged Young Aged + BB a/b = p ? 0.001 *** = p ? 0.001 PI3K TrkB Akt BDNF Enhancement of Hippocampal Protein Synthesis ERK PI3K TrkB mTOR Ho