LEPO,aNovelPodophyllotoxinDerivativeovercomesP-glycoprotein-mediatedMultidrugResistancein.docVIP

L1EPO, a Novel Podophyllotoxin Derivative overcomes P-glycoprotein-mediated Multidrug Resistance in K562/A02 Cell Line Hong CHENa,Bo CAOa Jiingzhe Zhanga Shufang BAIa,J Peng-Fei YUb, Jing WANG a,, Hong CHEN*a. a Medical College of Chinese People’s Armed Police Forces; Tianjin 300162, China: b Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University; Shenyang 110016, China. Abstract Ineffectiveness of anticancer drugs is frequently observed in cancer chemotherapy. The resistance of tumor cells to various cytotoxi