1980 Nobel Prize in Chemistry[Walter Gibert].pdfVIP

DNA SEQUENCING AND GENE STRUCTURE Nobel lecture, 8 December, 1980 by WALTER GILBERT Harvard University, The Biological Laboratories, Cambridge, Massachusetts 02138, USA When we work out the structure of DNA molecules, we examine the fundamen- tal level that underlies all process in living cells. DNA is the information store that ultimately dictates the structure of every gene product, delineates every part of the organism. The order of the bases along DNA contains the complete set of instructions that make up the genetic inheritance. We do not know how to interprete those instructions; like a