Angiogenesis.pdfVIP

Acta Neuropathol (2009) 117:481–496 DOI 10.1007/s00401-009-0483-6 REVIEW Angiogenesis after cerebral ischemia Heike Beck · Karl H. Plate Received: 7 November 2008 / Revised: 8 January 2009 / Accepted: 8 January 2009 / Published online: 14 January 2009 ? Springer-Verlag 2009 Abstract Though the vascular system of the adult brain is extremely stable under normal baseline conditions, endothelial cells start to proliferate in response to brain ischemia. The induction of angiogenesis, primarily in the ischemic boundary zone, enhances oxygen and nutri- ent supply to the aVected tissue. Additionall