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2017-04-13 发布于江苏
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Intervention on Obesity, Bright Liver, and Insulin Resistance.pdf

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Intervention on Obesity, Bright Liver, and Insulin Resistance

ORIGINAL ARTICLE Adenovirus-36 Seropositivity Enhances Effects of Nutritional Intervention on Obesity, Bright Liver, and Insulin Resistance Guglielmo M. Trovato ? Giuseppe Fabio Martines ? Francesca M. Trovato ? Clara Pirri ? Patrizia Pace ? Adriana Garozzo ? Angelo Castro ? Daniela Catalano Received: 29 November 2010 / Accepted: 31 August 2011 / Published online: 28 September 2011 Springer Science+Business Media, LLC 2011 Abstract Background Obesity and liver steatosis are both currently attributed to inappropriate lifestyle and nutrition. Higher prevalence of human adenovirus Ad36 seropositivity (Ad36?) is reported only in obesity. Aims To investigate whether a lifestyle-nutritional inter- vention achieves different outcomes in NAFLD patients, i.e., if is blunted or enhanced according to Ad36 seropos- itivity status. Methods One-year nutritional intervention was planned and accomplished for 62 non-alcoholic fatty liver disease overweight–obese patients, studied by liver ultrasound, evaluating Bright Liver Score (BLS), by Homeostatic Model assessment of Insulin Resistance (HOMA), by body composition and Ad36? assay. Lower salt/lower calories Mediterranean diet, physical activity increase, smoking withdrawal and lifestyle counseling, provided by a health psychologist, were given. Results Ad36 seropositive patients have baseline greater BMI with the same level of BLS. Different prevalence of post-interventional response, significantly greater among Ad36? patients, is observed: greater decrease of obesity, assessed by BMI, greater reduction of insulin resistance, assessed by HOMA and higher prevalence of bright liver disappearance. A BMI-adjusted multiple linear regression model explains significantly 23.8% (p \ 0.04) of the variance; significant predictive variables are Ad36 seropositivity (p \ 0.012) and fat mass loss (p \ 0.011) accounting for the variance of the occurrence of bright liver disappearance. Conclusions Ad36 previous infection is significantly associ