微生物发酵法生产灵菌红素研究进展.PDFVIP

1332 生物工程学报 尤忠毓 等/微生物发酵法生产灵菌红素研究进展 Chinese Journal of Biotechnology /cjbcn October 25, 2016, 32(10): 1332?1347 DOI: 10.13345/j.cjb.160047 ?2016 Chin J Biotech, All rights reserved 综 述 微生物发酵法生产灵菌红素研究进展 尤忠毓，王玉洁，孙诗清，刘晓侠 嘉兴学院 生物与化学工程学院，浙江 嘉兴 314001 尤忠毓, 王玉洁, 孙诗清, 等. 微生物发酵法生产灵菌红素研究进展. 生物工程学报, 2016, 32(10): 1332–1347. You ZY, Wang YJ, Sun SQ, et al. Progress in microbial production of prodigiosin. Chin J Biotech, 2016, 32(10): 1332–1347. 摘 要: 灵菌红素是一种微生物次级代谢产生的重要天然红色素，在医药开发、环境治理和染料制备等领域 具有巨大的潜在应用价值。文中从 3 个方面归纳了国内外关于灵菌红素的研究进展：产灵菌红素微生物的发现 与改造；灵菌红素发酵与提取过程的控制与优化；灵菌红素生物合成途径及其转录调控机制的解析。最后，讨 论了微生物发酵法生产灵菌红素今后的研究方向。 关键词: 灵菌红素，发酵生产，菌株选育，优化控制，合成途径，转录调控 Progress in microbial production of prodigiosin Zhongyu You, Yujie Wang, Shiqing Sun, and Xiaoxia Liu College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China Abstract: Prodigiosin is an important natural red pigment that is produced as a secondary metabolite by microorganisms, and has great potential applications in the field of pharmaceutical development, environmental management and dye preparation. This paper reviews recent research progress in the production of prodigiosin by microbial fermentation, including discovery and modification of the prodigiosin-producing microorganisms, regulation and optimization of prodigiosin fermentation and extraction process, and