血液科王飞博士SCI.pdf

Gambogic acid suppresses hypoxia-induced hypoxia- inducible factor-1a⁄ vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase⁄ Akt⁄ mammalian target protein of rapamycin pathway in multiple myeloma cells Fei Wang,1 Wei Zhang,2 Liting Guo,1 Wen Bao,1 Nan Jin,1 Ran Liu,1 Ping Liu,1 Yonghui Wang,3 Qinglong Guo4 and Baoan Chen1 1Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Medical School, Zhongda Hospital, Southeast University, Nanjing; 2Department of Pathology, Medical School, Southeast University, Nanjing; 3Department of General Surgery, Medical School, Zhongda Hospital, Southeast University, Nanjing; 4State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, China Key words In multiple myeloma (MM), the hypoxic environment is an important factor caus- Angiogenesis, gambogic acid, hypoxia-inducible factor 1 ing tumor angiogenesis, which is strongly correlated to disease progression and alpha subunit, multiple myeloma, vascular endothelial unfavorable outcome by activating the key transcription factor, hypoxia-inducible growth factor A factor-1a (HIF-1a). Gambogic acid (GA) is the major active ingredient of gamboge, Correspondence Baoan Chen, Department of Hematology which has been shown to possess antitumor effect by in vitro and in vivo study. and Oncology (Key Department of Jiangsu Medicine), The However, the underlying molecular mechanism of whether GA inhibits tumor Affiliated Zhongda Hospital, Medical School, Southeast angiogenesis remains poorly understood. In this study, we investigated the University, 87 Dingjiaqiao, Nanjing 210009, China.