不同胎龄新生儿感染性疾病降钙素原甲状腺激素水平测定的相关性研究1215.doc

《不同胎龄新生儿感染性疾病降钙素原、甲状腺激素水平测定的相关性研究》技术报告 张成元 张春磊 张海鲲 李雪峰 李丽 郑艳艳 山东省潍坊市妇幼保健院（261011） 中文摘要 目的 探讨不同胎龄新生儿感染时血清降钙素原、甲状腺激素水平变化及临床意义。方法 对2011年6月——2013年6月收治的新生儿感染性疾病按照胎龄划分为A组（小胎龄组早产儿，胎龄＜32周）、B组（大胎龄组早产儿，32≤胎龄＜37）、足月儿（胎龄≥37周）3组，测定其血清降钙素原（procalcitonin，PCT）、甲状腺激素水平（triiodothyronine T3、thyroxin T4、 thyroid stimulating hormoneTSH），同时纳入同期收治院的非感染性新生儿作为对照组。 结果 血清降钙素原水平：各胎龄组感染组均高于非感染组，其中A组感染组与非感染组差异有统计学意义，B组、C组感染组、非感染组有显著统计学意义。甲状腺激素水平： A组、B组感染组与非感染组有显著统计学意义， C组感染组与非感染组有统计学意义。（P＜0.05 有统计学意义，P＜0.01 有显著统计学意义）。结论 降钙素原是新生儿感染重要诊断指标，不同胎龄新生儿血清降钙素原水平有所不同，大胎龄儿降钙素原水平变化更能反映感染。甲状腺激素水平也可作为新生儿感染的参考指标之一，胎龄越小，越易发生暂时性甲状腺功能低下。 关键词：婴儿 新生儿 早产 感染 降钙素原 甲状腺激素 ABSTRACT Relationship between procalcitonin, thyroid hormone levels and infection disease of infants in different gestational age Abstract :Objective To research the changes of procalcitonin and thyroid hormone levels from infection disease of infants in different gestational age. Method Dividing infectious diseases in accordance with the gestational age was divided into 3 groups from 2011 June -- 2013 in neonates admitted in June : group A (little for gestational age infants, large for gestational age 32 weeks), group B (large for gestational age infants, 32 ≤ gestational age 37), full-term infants (gestational age 37 weeks), determination of the PCT, thyroid hormones (T3, T4, TSH) (T3 triiodothyronine, T4 thyroxin, TSHthyroid stimulating, hormone), at the same time compared with non infectious newborns admitted in the same period as the control group of academy. Result The levels of serum procalcitonin: fetal infection group were higher than that of non infection group, group A, infection group and non infection group, the difference was statistically significant, group B, group C， infection group, non infection group had statistical significance. Thyroid hormone level: group A, group B, infection group and non infection group was statistically significant, group C the infection group and non infection group had statistical signifi