08章肌松藥应用.pptVIP

第八章 肌松药的临床应用;目的与要求;Key;History ;Clinical Use;Molecular Features ;Muscle relaxants are generally quite water-soluble The water solubility of relaxants inhibits uptake into hepatocytes Metabolism and/or excretion in the liver is usually not a major pathway of elimination The muscle relaxants are easily excreted by glomerular filtration in the urine ;Class;PHARMACOLOGY  OF SUCCINYLCHOLINE ;Cardiovascular Effects ;Sinus Bradycardia with high sympathetic tone, such as children in adults and appears more commonly after a second dose of the drug is given approximately 5 m