ProductionGroup.pptVIP

Production Group;Production Group;Rodjana Chunhabundit Toxicology Program, Faculty of Science Mahidol University;Outlines;The Need for HIV Vaccine;Requirements for an HIV vaccine;Current Strategies for an HIV Vaccine;Inactivated or Killed Vaccines;Preparation of the inactivated whole-virus vaccine derived from a proviral DNA clone of SIV;Preparation of the Inactivated Whole-virus Vaccine Derived from a Proviral DNA Clone of SIV;Live Attenuated Vaccines;Strategy for Deleting Part of the Cholera Toxin A1 Peptide DNA Sequence;Limitations of Traditional Vaccines;Subunit Vaccines;Immunization with gp 120 or recombinant vaccinia virus coding for the HIV gp 160 induce T-cell mediated IR. Neutralizing epitopes are presented on both gp 120 and gp 41 proteins. Immunization in chimpanzees with purified gp 120 has failed to protect against infection with HIV-1.;Development of the Full-length Envelope Glycoprotein;Large-scale Production of a Vaccine Recombinant Derived HIV-1 gp 160; Production of Recombinant Virus Stocks;Large-scale Cultivation of Vero Cells;gp 160 Production;;Peptide Vaccines;Preparation of the Hybrid T1-SP10 Peptide;Live Vector-Based Vaccine;Method for the Integration into Vaccinia Virus of a Gene Whose Protein Product;DNA Vaccines;Clinical Trials of HIV Vaccines;Phase III trial - placebo-controlled, randomized and double-blind studies - number of volunteers is determined by incidence of infection rate and statistical parameters of protection - be performed only in the most promising candidate vaccines - target populations, including Homosexual men, intravenous drug users, prostitutes, prisoners, newborn of seropositive mother, and seual transmitted disease patients;Phase of Clinical Trials of a Candidate AIDS Vaccine;AIDS Vaccines Currently in Clinical Trials;Conclusion