草酸铂联合氟尿嘧啶、醛氢叶酸治疗晚期结直肠癌的临床观察的论文.docVIP

　　草酸铂联合氟尿嘧啶、醛氢叶酸治疗晚期结直肠癌的临床观察的论文 【摘要】 目的 观察草酸铂（lohp）联合氟尿嘧啶(5fu)、醛氢叶酸（lv）作为一线方案治疗晚期结直肠癌的临床疗效和耐受性。方法 23例晚期结直肠癌，其中结肠癌11例，直肠癌12例，初治8例，复治15例 ，化疗前均经肘正中静脉留置静脉留置针。lohp 65 mg/m2,静脉滴注4 h，d1；lv 200 mg/m2静脉滴注2 h,5fu 0.5 g/m2于cf静点完后静脉推注,续以5fu 2.4～3.0 g/m2持续静脉滴注48 h，21天为1周期，连用2周期评价疗效 。按en for patients or heilongjiang province daqing peoples hospital tumor branch harbin medical college daqing school district pathology department,daqing163316,chinaabstract：objective the goal observation oxalic acid platinum (lohp) unites the fluorine uracil (5fu), aldehyde hydrogen folic acid (lv) to take a plan treatment later period colon cancer the clinical curative effect and the tolerance.methods 23 example later period colon cancer, the colon cancer 11 examples, the rectal cancer 12 examples, initially govern 8 examples, duplicate governs 15 examples, before the chemotherapy, passes through the elboedian vein leaving alone vein leaving alone needle. lohp65 mg/m2, the vein drop pours for 4 hours, d1; the lv200 mg/m2 vein drop pours for 2 hours, 5fu0.5 g/m2 pushes the note after the cf dead center vein, continues continues the vein drop by 5fu2.4～3.0g/m2 to pour for 48 hours, 21 days are 1 cycle, are used together 2 cyclical appraisal curative effect. according to ple, the pr9 example, effectiveness (cr+pr) 47.8%, initially governs effectiveness is 62.5%, duplicate governs effectiveness is 45.4%, statistics processing not obvious difference (pgt;0.05). main poisonous side reaction for disgusting, vomit (74%), oral cavity mycodermatitis and diarrhea 59.2%, as unites the 5fu/lv plan treatment later period colon cancer effectiveness to be high, the tolerance is good, the untootion. key otherapy；advanced colorectal cancer 晚期结直肠癌是我国最常见的消化道恶性肿瘤,其发病率和死亡率均占我国常见恶性肿瘤的前5位。.cOm由于早期诊断率较低，大多病人确诊时已属晚期，手术切除机会少，加上术后复发，使大部分病人主要靠内科治疗，因此，化疗对于晚期结直肠癌患者有重要意义。近年来一些新的治疗方法和新抗肿瘤药物??涌现，使晚期结直肠癌的临床化疗疗效和可耐受性取得了长足的进步[1]。 草酸铂是继顺铂和卡铂之后上市的第三代铂类抗癌药，具有抗癌活性高、抗瘤谱广，与顺铂无交叉耐药，不良反应轻的优点，在体外和体内的临床研究表明草酸铂对消化道肿瘤有显著的抑制作用。我院于2