SodiumChromateCr51Injection.PDF

Sodium Chromate Cr 51 Injection Package inserts are current as of January, 1997. Contact Professional Services, 1-888-744-1414, regarding possible revisions. Click Here to Continue Click Here to Return to Table of Contents Sodium Chromate Cr 51 Injection 370,372,374 A370I0 Diagnostic—For Intravenous Use Revised 3/96 DESCRIPTION 51 Sodium Chromate Cr 51 (Na2 CrO4) Injection is available for diagnostic use as a sterile, non-pyrogenic solution. Each milliliter contains 3.7 megabecquerels (100 microcuries) chromium Cr51 on the calibration date, and 0.5 milligrams sodium bicarbonate as a buffer. The pH is adjusted to between 7.5 and 8.5 with hydrochloric acid or sodium hydroxide. The specific activity is at least 370 megabecquerels (10 millicuries) per milligram of sodium chromate. PHYSICAL CHARACTERISTICS Chromium-51 decays by electron capture with a physical half-life of 27.7 days.1 The principal photon useful for detection is listed in Table 1. Table 1: Principal Radiation Emission Data1 Mean Percent Per Energy Radiation Disintegration (keV) Gamma-1 9.83 320.1 EXTERNAL RADIATION The specific gamma ray constant for chromium Cr51 is 0.18 R/mCi-hr at 1 cm. The first half-value thickness is 0.17 cm of lead (Pb). A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 2. For example, the use of a 1.68 cm thickness of Pb will decrease the external radiation exposure by a factor of about 1,000. Table 2: Radiation Attenuation by Lead Shielding Shield Coefficient of Thickness (Pb) cm Attenuation 0.17 0.5 0.56 10 -1 1.12 10 -2 1.68 10 -