肥胖伴高密度脂蛋白降低机制新进展.docxVIP

第一章 前言 随着生活环境改变、能量摄入过多、体力活动减少等生活方式改变，代谢综合征(metabolic syndrome，MS)成为了影响全世界公共健康和临床疾病的主要并逐渐恶化的问题。 MS主要为一组包括腹型肥胖、胰岛素抵抗、高血压、甘油三酯（TG）升高及高密度脂蛋白（HDL）降低的主要临床表现的代谢症候群 ADDIN EN.CITE EndNoteCiteAuthorPotenza/AuthorYear2009/YearRecNum41/RecNumDisplayText[1]/DisplayTextrecordrec-number41/rec-numberforeign-keyskey app=EN db-id=da5svxawov0psresaru5xatavrvf2szezs9p timestamp=139953831441/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorPotenza, M. V./authorauthorMechanick, J. I./author/authors/contributorsauth-addressMount Sinai Hospital, One Gustave L. Levy Place, New York, NY 10029, USA. doctor.potenza@/auth-addresstitlestitleThe metabolic syndrome: definition, global impact, and pathophysiology/titlesecondary-titleNutr Clin Pract/secondary-title/titlesperiodicalfull-titleNutr Clin Pract/full-title/periodicalpages560-77/pagesvolume24/volumenumber5/numberedition2009/10/21/editionkeywordskeywordAnimals/keywordkeywordCacao/keywordkeywordChromium/keywordkeywordCinnamomum zeylanicum/keywordkeywordComplementary Therapies/ methods/keywordkeywordDiet/ methods/keywordkeywordDietary Fiber/keywordkeywordFatty Acids, Omega-3/keywordkeywordFishes/keywordkeywordHumans/keywordkeywordLinseed Oil/keywordkeywordMagnesium/keywordkeywordMetabolic Syndrome X/diagnosis/ diet therapy/physiopathology/keywordkeywordRisk Factors/keywordkeywordSoybean Proteins/keywordkeywordStilbenes/keywordkeywordWine/keyword/keywordsdatesyear2009/yearpub-datesdateOct-Nov/date/pub-dates/datesisbn0884-5336 (Print)#xD;0884-5336 (Linking)/isbnaccession-nuaccession-numurlsrelated-urlsurl/content/24/5/560.long/url/related-urls/urlselectronic-resource-num24/5/560 [pii]#xD;10.1177/0884533609342436 [doi]/electronic-resource-numremote-database-providerNlm/remote-database-providerlanguageeng/language/record/Cite/EndNote[1]；诊断代谢综合征的患者5到10年内得心血管疾病的相对风险增加2倍，2型糖尿病的相对风险增加5倍 ADDIN EN.CITE  ADDIN EN.CITE.DATA [2]。而肥胖和胰岛素抵抗被认为是代谢综合征的核心因素。白色脂肪组织是体内最大的脂质储存库，而白色脂肪组织增生肥大导致肥胖。除作为机体最大的甘油三酯及游离胆固醇