1 case of allergy rituximab Nursing.docVIP

 PAGE \* MERGEFORMAT 6 1 case of allergy rituximab Nursing [Keywords:] Rituximab; allergy; Care Non-Hodgkin lymphoma (NHL) is a common lymphoid malignancies, of which the vast majority of B cell origin. Rituximab (MabThera) is a chimeric mouse / human monoclonal antibody, the antibody runs through the cell membrane CD20 antigen-specific binding, induced B cell apoptosis, inhibit cell proliferation. Treatment of CD20-positive resistance to chemotherapy low grade follicular lymphoma, 60% efficient single-agent, and the CHOP regimen in combination, efficient 96%. Compared with the standard CHOP scheme, the French GELA study results show that rituximab and CHOP regimen in combination (P-CHOP) treatment of aggressive large cell NHL has significant advantages, the treatment of invasive large cell NHL standard first-line [1]. Therefore, in clinical to be widely used. our department the last 3 years, 50 cases of NHL patients with this regimen, 1 patient in the August 28, 2009 in the intravenous infusion of rituximab after 15min an allergic reaction occurs, the active rescue, the patient out of danger of the Security through chemotherapy. now nursing reported as follows. A medical record Patients, male, aged 35, found the right cervical lymph nodes a more than a month, in August 2009 received treatment in local hospitals, the removal of lymph nodes, immune pathological examination revealed non-Hodgkin’s lymphoma, CD20 (+). Past the body health, no history of drug allergy. into the Division when the blood was WBC 5.6 109 / L, neutrophils 67.1%, 14.6% lymphocytes, monocytes 16.7% In 2009 Aug. 28 patients in the intravenous infusion of rituximab 15min after the completion of a sudden difficulty in breathing, facial flushing, upper limbs twitch, with chills. checkup: T 37.9 , R 28 times / min, HR 108 times / min, BP 110/70mmHg, conscious, answering to the point, the body scattered rash, lung auscultation, and a small amount of phlegm could be heard sounds, abdo