12 months old Apoe-- - atherosclerotic mouse heart liver and renal lesions characterized.docVIP

 PAGE \* MERGEFORMAT 9 12 months old Apoe-/ - atherosclerotic mouse heart liver and renal lesions characterized Of: Tian Feng Zhang W Kang Aijun banyan Zhoushu Pei Zheng Zhenhui Ming Zhao Abstract Objective 12-month-old Apoe-/ - atherosclerotic mouse heart, liver and kidney lesions. Methods 12 month old male and female mice with atherosclerosis, and age 20 with the number of male and female C57BL / 6J mice were used as controls, with automatic biochemical analyzer and heart function, liver function and kidney function associated serum enzymes; to Intelligent non-invasive blood pressure measurement SoftronTM mouse heart rate and blood pressure; routine pathological producer, HE staining, optical microscopy heart, liver and kidney pathology. Results of female Apoe-/ - mice kidney function related to blood urea nitrogen (BUN) compared with control mice was significantly increased (P lt;0.01), male Apoe-/ - mice kidney function related to serum creatinine (Cr) and uric acid (UA) were significantly higher (P lt;0.01). Other indicators compared with the control group, no significant difference. Female Apoe-/ - mice systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MBP) compared with the control group were significantly different (P lt;0.05), male Apoe-/ - mice DBP and MBP Compared with the control group were significantly different (P lt;0.05), heart rate (HR) no significant changes. 4 cases of Apoe-/ - mice shows renal artery medial wall thickening, a large number of foam-like cell proliferation. Conclusion 12 month old Apoe-/ - mice with atherosclerotic lesions of renal function significantly. Keywords: Apoe-/ - mice; heart; liver; kidney The Apoe-/ - atherosclerosis, whether normal or high fat diet mice, severe hyperlipidemia can be formed, and the spontaneous formation of fibrous plaques and complex patches, and patch distribution and human atherosclerosis very similar to the distribution of plaques