1 5 cases of familial hematuria-based pedigree analysis of IgA nephropathy.docVIP

 PAGE \* MERGEFORMAT 10 1 5 cases of familial hematuria-based pedigree analysis of IgA nephropathy 【Key Words】 gA nephropathy IgA nephropathy is a pathological diagnosis of immune name. As early as 70 years in the 20th century, someone noted that in the relatives of IgA nephropathy in a higher incidence of abnormal urine test. Early 80s were also reported 290 cases of British patients with IgA nephropathy in 3.8% had a family history of kidney disease [1]. IgA nephropathy is not associated with a group of systemic diseases, renal biopsy pathology in the immune mesangial district to granular deposition of IgA-based clinical practice with hematuria as the main performance of glomerular nephritis [2 ]. The incidence of IgA nephropathy in China accounted for 26% of glomerular diseases, 34%, a higher incidence of males, there is a certain degree of familial, more than one person in the same family illness, manifested as asymptomatic urinary abnormalities (experimental inspection hematuria or protein urine), recurrent gross hematuria or chronic renal insufficiency [3]. We report five cases of a house property of IgA nephropathy. A clinical data 1.1 General Information From January 2002 to August 2007, five cases of hospital out-patient diagnosis and treatment of a urine-based patients, 2 males (father and son), 3 females (sisters). Big Sister in 2002 suffering from hematuria cause is unclear, poor efficacy, the latter due to ineffective treatment for uremia patient died at the age of 38. 36-year-old younger brother, renal insufficiency, hypertension, high proteinuria, hematuria, edema has been three years, the blood IgA-positive, after more than five years of western medicine in hospitals, there is repeated hematuria. Sanmei 34 years old, in 2006, due to uremia, proteinuria, hematuria, serum IgA-positive, Chinese herbal treatment for 4 years, I died. Simei (with Sanmei twin sister), renal failure, hematuria, blood pressure (140/96mmHg),