218 patients after heart valve replacement Analysis of warfarin therapy.docVIP

 PAGE \* MERGEFORMAT 7 218 patients after heart valve replacement Analysis of warfarin therapy [Abstract] Objective: To study the oral anticoagulants after heart valve replacement therapy, the use of determination of prothrombin time (PT) international normalized ratio (INR) evaluation of the allowable range of anticoagulation. Methods: different gender, age, the number of valve replacement, postoperative course, and the amount of 218 warfarin patients PT test results were analyzed. Results: The treatment to achieve the same purpose, the INR PT female patients than male patients to the allowable range (P lt;0.01, with postoperative course of the extension and increase the dose, PT INR, increasing slightly the allowable range. Conclusion: The oral anticoagulants after heart valve replacement PT INR monitoring allows the range of 2.10 + -0.52, than the United States and European countries The recommended value is low, sex and the use of time and dose not the same, PT INR monitoring the extent permitted by different, so treatment should pay attention to individual differences. [Keywords:] valve replacement surgery, anticoagulation therapy 218 patients in our hospital oral anticoagulants after heart valve replacement therapy clinical analysis of PT test results and summary. 1 Subjects and methods 1.1 The choice of cases were 218 patients from September 1996 to September 2006 in our hospital surgery and long-term follow-up treatment in our hospital with rheumatic heart valve disease are the use of mechanical type valve, male 106 cases, 112 cases of women, age 18 to 74 years after surgery treatment for 1 to 17 years, 98 cases of replacement of a valve, 2 valve 120 cases. All the cases have been about 4 weeks to adjust the time, warfarin therapy in patients entering the maintenance phase. taking warfarin Falin Wei holds a daily dose of 0.75 ~ 9.00mg. In this summary of the study period, these patients had no clinical signs of thrombosis formation, and n