89Sr internal radiotherapy in patients with prostate cancer 37 cases of multiple bone metastasis.docVIP

 PAGE \* MERGEFORMAT 6 89Sr internal radiotherapy in patients with prostate cancer 37 cases of multiple bone metastasis Study: Forest Liu Dan Yan Li Ying Hua Wangqi Hou Guan Feng Cheng He [Keywords:] 89 Sr; internal radiation therapy; prostate cancer; bone metastases Current clinical prostate cancer (PCa) bone metastasis therapy are external beam radiation therapy, pain medication, surgery and internal radiation therapy radionuclide. The treatment of elderly PCa 89Sr through the application of multiple bone metastases, and analyze its effect. 1 Materials and Methods 1.1 The object of study from January 2008 to June 2009 in our department of elderly PCa treatment of bone metastases in 37 cases, aged 60 to 88 years (mean 68.5 +5.8 years), duration of 1 to 13 months. Typical clinical manifestations of systemic many different degrees of bone pain, some accompanied by fractures, motor dysfunction. 1.2 The inclusion criteria should have the following 3 points in older patients: (1) diagnosed with PCa; (2) whole body bone scan and multiple abnormal radioactivity increased area, diagnosed as multiple bone metastases; (3) WBCgt; 3.0 109 / L, liver and kidney function was normal. 1.3 Treatment (1) pre-treatment preparation: Disable calcium and high calcium foods 2 w, OK Bone Scan and Serum PSA, liver and kidney function, blood routine examination; (2) in the treatment of radioactive drugs and Methods: The venous access After intravenous injection, radioactive drugs 89SrCl2 (trade name thinking through Ning, Shanghai Atomic Sinovac Pharmaceutical), dosage are 4 mCi, 32 cases 1 treatment, 5 cases an interval of 3 to 6 months 2 therapy; (3) After treatment, the first check within 1 month of weekly routine, the first 1,3 months, liver and kidney function and blood routine review, the first 3 months, 6 months later and the whole body bone scan PSA. 1.4 Evaluation of complete remission treatment (CR): no pain after treatment; partial remission (PR): Pa