A low dose of cyclosporine in heart transplantation.docVIP

 PAGE \* MERGEFORMAT 12 A low dose of cyclosporine in heart transplantation Study: Dongshan Liu, Zeng-Qi, LIU Chong-xian, CHEN Dao, the Liang-million [Abstract] Objective To investigate the low-dose cyclosporine A (CsA in cardiac transplantation safety and effectiveness. Methods 57 patients after allogeneic heart transplantation to be a different immunosuppressive regimen: group 1 for the traditional triple program-CsA + mycophenolate mofetil (MMF + prednisone (Pred treatment before surgery for group 2 human monoclonal anti-interleukin 2 receptor antibody + / anti-lymphocyte globulin (ALG / ATG induction, continued to pick him tacrolimus (FK506 + MMF + Pred, 3 preoperative Daclizumab induction, after 1 ~ 3 d of methylprednisolone transition, after the first 4 days follow CsA + MMF (2 g / d + Pred, CsA trough blood concentration of control in the 100 ~ 150 ng / mL. the results of postoperative renal dysfunction, acute rejection and other complications, the highest incidence in group 1, group 2 was significantly reduced in group 3 at least, the first 3 groups compared with the previous two were statistically significant differences (P lt;0.05. Conclusions CsA immunosuppression after heart transplantation in the treatment of, and fully demonstrate its safety, effectiveness and economy. [Keywords:] Heart transplantation, cyclosporine, immunosuppressive agents, transplantation, homologous Heart transplantation is the treatment of advanced heart disease is an effective means, has been widely carried out, but after immunosuppressant there are many disputes. The author concluded in August 1995 -2005 implemented in June were 57 cases of allogeneic orthotopic heart transplantation with different immunosuppressive effect, reported as follows. 1. Subjects and methods 1.1 Object receptor 57 cases, male 46, female 11, age (36 + -24 years (12 to 60 years of age, body weight 37 ~ 80 kg. All patients by ECG, echocardiography, chest X-ray films such as diagnosi