About TGP combined with vitamin D3 on the serum of patients with rheumatoid arthritis IFN-γ and IL-10 effect.docVIP

 PAGE \* MERGEFORMAT 12 About TGP combined with vitamin D3 on the serum of patients with rheumatoid arthritis IFN-γ and IL-10 effect [Abstract] Objective To observe the TGP (TGP) combined with vitamin D3 adjuvant treatment of rheumatoid arthritis (RA) in serum of patients before and after interferon γ (IFN-γ) and interleukin 10 (IL-10) levels of The treatment of the immunological mechanisms of RA. Methods Using enzyme-linked immunosorbent assay (ELISA) detection combined with vitamin D3 TGP RA patients before and after adjuvant treatment of serum IFN-γ, IL-10 concentrations, and evaluation of disease activity and efficacy in patients. Results in RA patients with IFN-γ in higher than the control group (P lt;0.01), IL-10 levels lower than the control group, but the difference was not statistically significant (Pgt; 0.01); TGP combined with vitamin D3 in the serum levels of IFN-γ reduced (Pgt; 0.05), IL-10 levels were significantly increased (P lt;0.01). Conclusion TGP and Vitamin D3 can reduce the serum of RA patients with IFN-γ levels, while elevated levels of IL-10 is beneficial inhibition of Th1 type cytokines, while enhancing the effects of Th2 type cytokines, which can improve the condition of patients with RA. [Keywords:] TGP, vitamin D3, rheumatoid arthritis, interferon γ, interleukin -10 Keywords:: total glucosides of paeony, vitamin D3, rheumatoid arthritis, IFN-γ; IL-10 TGP (TGP) with vitamin D3 treatment of rheumatoid arthritis in recent years, a significant drug effect. TGP is the dried root of peony root extract from the active ingredient, containing paeoniflorin, hydroxyl paeoniflorin, peony flower glycosides, peony lactone glycosides and so on. pharmacological studies have shown that, TGP has a variety of ways to inhibit the autoimmune response [1], and anti-inflammatory, pain, liver protection effect on the treatment of autoimmune diseases show a good prospect. Vitamin D3 not only involved in calcium and phosphorus metabolism, improv