Acellular dermal allograft tissue patch in the treatment of complex urethral stenosis.docVIP

 PAGE \* MERGEFORMAT 12 Acellular dermal allograft tissue patch in the treatment of complex urethral stenosis Of: Huang Chao, Yang Fengguang, Zhang Yanrong, He Yanyu [Abstract] Objective To observe the acellular allogeneic dermal tissue patch (AMG) treatment of complex urethral stricture of urethral reconstruction in clinical efficacy, for an ideal urethral repair material. Urethral reconstruction method to AMG as an alternative material, the treatment of male patients with complex urethral stricture in 25 cases, surgery will be assembled into tubular AMG to replace urethral defect, 4 weeks after removal of the catheter. resumption of voiding after the results of catheter removal in 25 cases, angiography showed that the urethra urethral continuity is good, after 1 AMG said on bladder and urethra mirror cavity surface urothelial cells have been covered, and the urethra can not be distinguished from the body. 2 to 6 months after recurrence of urethral stenosis in 4 cases, including 2 cases of urethral dilation, urethral cut in 2 cases open surgery, the patient can urinate through the urethra normal. Conclusions AMG is an ideal urethral substitute material, suitable for multi-segment or long segment urethral stricture or defect. [Keywords:] urethra, urethral stricture, dermis; extracellular matrix; Transplantation, Homologous ABSTRACT: Objective To evaluate homologous dermal acellular matrix graft (AMG) for urethral reconstruction in the treatment of complex urethral stricture and to find an ideal replacement material to simplify the urethroplastic surgery. Methods Twenty five male patients with complex urethral stricture were treated with allograft of tissue engineering material AMG, which was sutured into a tubular graft to replace the defective urethra. The catheters were retained in the reconstructed urethrae for 4 weeks. Results All 25 patients were voiding well after the removal of the catheters. Urethrography revealed excellent urethral continui