Achyranthes bidentata extract sciatic nerve regeneration factor to promote regeneration in mice.docVIP

 PAGE \* MERGEFORMAT 14 Achyranthes bidentata extract sciatic nerve regeneration factor to promote regeneration in mice [Abstract] Objective To observe the effects of Achyranthes bidentata extract of nerve regeneration factor (NRF) on mouse sciatic nerve injury repair. Methods ICR mice were 50 male and female in half, OK folders sciatic nerve injury patients were randomly divided into 5 groups: NRF high, middle and low-dose group, Methycobal group (positive control), saline group (blank control). After intraperitoneal injection daily administration. Use of mouse sciatic nerve function index (sciatic function index, SFI), histological and electron microscopy to observe the impact of NRF on the sciatic nerve injury. Results Compared with the control group, NRF can significantly improve the sciatic nerve function in mice. Ultrastructural observation showed that the experimental group, myelinated nerve fibers of the myelin sheath morphology, thickness, maturity compared with the control group, while the number of fiber degeneration than the control group. Conclusion NRF after sciatic nerve injury in mice can promote the repair and functional recovery. [Keywords:] bidentata; nerve regeneration factor; sciatic nerve injury; nerve regeneration Abstract: ObjectiveTo investigate the repair effect of nerve regeneration factor (NRF) extracted from Achyranthes bidentata Blume (BL) on the crushed sciatic nerve of mouse. MethodsFifty ICR mice suffered from the sciatic nerves crush were used in the experiment. The animals were randomly divided into five groups: three NRF groups (low, middle and high dose), Mecobalamin group (positive control) and blank control group. These mice after sciatic nerves crush received NRF by intraperitoneal injection every day. Sciatic function index (SFI) was tested every 4 days. Histomorphology and ultra-structure were used to the study on the 21th day. ResultsCompared with the black control group, SFI in NRF group and the section area of the