Acyclovir and gamma globulin efficacy of combined treatment of children HSE.docVIP

 PAGE \* MERGEFORMAT 10 Acyclovir and gamma globulin efficacy of combined treatment of children HSE [Abstract] Objective To investigate different doses of acyclovir combined with gamma globulin treatment of herpes simplex virus encephalitis patients. Methods 40 children were randomly divided into four groups, the routine combined therapy based on acyclovir glycoside and gamma globulin, the dose of acyclovir is divided into 10 mg / (kg · times) and 15 mg / (kg · times), with 100 ml normal saline were added intravenously every 8 h 1 times; uniform dose of gamma globulin was 200 mg / (kg · d). the results of a simple application of acyclovir 10 mg / (kg · times) group than with the simple application of acyclovir 15 mg / (kg · times) group the difference was not statistically significant, the differences with the other three groups were statistically significant. combined with acyclovir 15 mg / (kg · times), and gamma globulin 200 mg / (kg · d) higher than the efficacy of group the other three groups. Conclusion combination therapy is superior to single drugs with anti-virus. In acyclovir medication recommended dose range, appropriate choice of dose limiting drug use, and then gamma globulin combined with good effect. [Keywords:] viral encephalitis; herpes simplex virus; acyclovir; gamma globulin Herpes simplex virus encephalitis (herpes simplex virus encephalitis, HSE) is a herpes simplex virus (herpes simplex virus, HSV) causes the central nervous system viral infection. Is a common fatal sporadic encephalitis. Mainly involving the temporal brain Ye, frontal and limbic system, causing hemorrhagic necrosis of brain tissue and brain damage allergy, also known as acute necrotizing encephalitis or hemorrhagic encephalitis. HSE disease at any age can be about 2 / 3 of the cases occurred in adults 40 years of age, the incidence of non-seasonal. Foreign HSE incidence of 4 to 8 / 10 million, the prevalence was 10/10 million, the mortality was 40% to 70% [1]. he