Adenosine and ischemic postconditioning on myocardial ischemia-reperfusion in rabbits protection.docVIP

 PAGE \* MERGEFORMAT 13 Adenosine and ischemic postconditioning on myocardial ischemia-reperfusion in rabbits protection OF: He Xiaonan Shu-Mei Wang Xuemei Chen Yu [Abstract] Objective of adenosine on ischemia-reperfusion myocardial protection, and its relationship with ischemic postconditioning. Methods 40 healthy rabbits were randomly divided into control group, the antagonist group, ischemia treatment group, adenosine treatment group 4, n = 10. Preparation of in vivo model of myocardial ischemia, myocardial systolic function parameters, measurements of myocardial infarction, ischemia reperfusion observed immediately after application of adenosine and ischemia on rabbit myocardial ischemia and reperfusion. The results adenosine treatment group and ischemic postconditioning group compared with the control group and the antagonist group, reperfusion after the peak left ventricular pressure, maximal rate of rise of left ventricular pressure and left ventricular the maximum rate of pressure recovery rate declined significantly (P lt;0.05, infarct size was significantly lower than the control group and the adenosine receptor antagonist group (P lt;0.01, myocardial enzyme LDH and CK levels than the control group and the gland glycoside receptor antagonist group was significantly lower (P lt;0.01. Conclusion adenosine / adenosine receptor pathway is an important way of ischemic postconditioning, one can reduce ischemia-reperfusion injury, protect the myocardium. [Keywords:] ischemia-reperfusion injury, ischemic postconditioning, adenosine Animal tests confirmed that adenosine in myocardial ischemia-reperfusion injury has a protective effect, can reduce infarct size, improve left ventricular function and increased coronary blood flow (1,2). The role of adenosine in ischemic preconditioning has been relatively clear, In regard to adenosine in the ischemic postconditioning (3) the role of domestic and there are few reports of this study was to investigate a