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Adiponectin on human umbilical vein endothelial cells expression of CD55 and CD59
PAGE \* MERGEFORMAT 11
Adiponectin on human umbilical vein endothelial cells expression of CD55 and CD59
[Abstract] Objective To observe adiponectin on human umbilical vein endothelial cell complement regulatory proteins CD55 and CD59 expression. Methods Cultured human umbilical vein endothelial cells, divided into control group, C-reactive protein (CRP group and adiponectin group , respectively, in human umbilical vein endothelial cells with 50 g / ml for CRP and 25 g / ml of adiponectin were incubated 48 h, CD55 and CD59 by flow cytometry the expression. Results CRP mean fluorescence intensity after stimulation with CD55, CD59 average fluorescence intensity and percentage of CD55-positive compared with blank control group (3.84 + -0.21 compared with 2.81 + -0.06, P lt;0.001,69.72 + -4.48 compared with 51.15 + -7.86, P lt;0.01,98.30 + -1.13 93.57 + -1.18 compared , P lt;0.001), adiponectin stimulated CD59 and CD55 mean fluorescence intensity of the positive percentage is higher than the blank control group (63.02 + -4.90 compared with 51.15 + -7.86, P lt;0.05,96.55 + -0.66 + -1.18 compared with 93.57, P lt;0.01. Conclusion adiponectin is a human umbilical vein endothelial cells express CD55 and CD59 upregulation of factors, and endothelial cells by upregulating the expression of CD55 and CD59 play an anti-inflammatory, anti-atherosclerotic effect.
[Keywords:] adiponectin, complement regulatory protein, atherosclerosis
Adiponectin is an adipocyte-specific adipocytokine secretion, glucose and lipid metabolism conciliation and characteristics of anti-atherosclerosis. C-reactive protein (CRP) can activate the classical complement path and a role in promoting atherosclerosis. In recent years, The study found that peripheral blood lymphocytes in patients with hyperlipidemia CD55, CD59 downregulation (1), CD55 positive lymphocytes and mean fluorescence intensity of waist circumference, waist-hip ratio and negatively correlated with CRP (2), a positive corre
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