Advanced glycation end product receptor and Alzheimers disease.docVIP

 PAGE \* MERGEFORMAT 15 Advanced glycation end product receptor and Alzheimer’s disease [Keywords:] advanced glycation end products receptor, Alzheimer’s disease, amyloid protein Alzheimer’s disease (AD) is a kind of memory loss and cognitive dysfunction as the main manifestation of neurodegenerative diseases, to form a cell outside the amyloid plaques, neurofibrillary tangles inside cells and cells of chronic inflammation as the main pathology (1). amyloid protein (A) is an easy non-specific binding protein accumulation, with many different structures can be a combination of substances, such as lipid bilayers, proteoglycans and a variety of protein receptors, including advanced glycation end product receptor (RAGE), nicotinic acetylcholine receptor @ (@ N AChR), macrophage scavenger receptor type A (SR A), @ 51 integrin, N-methyl D aspartate receptor (NMDA receptor), p75 neurotrophin receptor (P75NTR) and low density lipoprotein receptor-related protein (LRP 1) (2) and so on. Recent studies show that, A accumulation in the nerve cells outside before on the emergence of clinical symptoms and memory loss and other brain cells also found a large number of synaptic loss (3,4), suggesting that in the early stages of AD, A monomer or oligomer with the molecular target binding, activation of the corresponding cells signaling pathways, leading to oxidative stress, neuronal toxicity level linking reaction is caused by nerve damage may be an important reason (5). This article summarizes the research results in recent years cell surface receptor RAGE and the relationship between the pathogenesis of AD, as AD The treatment of new ideas. 1 RAGE structure and distribution of 1992, Neeper RAGE protein was first found by the 404 amino acids, belonging to the cell surface immunoglobulin superfamily member. RAGE is a multi-ligand receptor, ligand addition to advanced glycation end products (AGEs) , also found that A, neurite growth factor (Amphoterin) / high mobil