Adhesion molecules and their role in liver metastasis.docVIP

 PAGE \* MERGEFORMAT 17 Adhesion molecules and their role in liver metastasis Tumor invasion and metastasis of tumor cells was an early process includes the capture of the target tissue, adhesion and metastasis of tumor cells to the blood vessels outside the walk. Distributed in vascular endothelial cell surface adhesion molecules, such as E-selectin can cycle on the surface of tumor cells in their rolling, E-selectin and its ligand LeX (a) and sLeX (a) endothelial cells, but can be and tumor cells, early identification and capture of the key adhesion molecules. In other tumor cell surface molecules such as integrin, intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) and extracellular matrix molecules in co-participation of the transfer of tumor cells in tumors could be completely stopped rolling and make cells and vascular endothelial cells closely. This combination eventually led to the wall of tumor cells into the target tissue Tour bleeding, then gradually formed a metastasis. Can be assumed that (1) in liver cancer occurrence and development of the process of adhesion molecule expression and expression regulation will have abnormal changes. (2) in the prevention of recurrence and metastasis of liver cancer, anti-adhesion therapy would be a new method of treatment. Hepatocellular carcinoma and vascular endothelial cells adhesion molecule expression: E-cadherin (E-cadherin): E-cadherin gene located on chromosome 16q22.1. It is an important biological function is mediated by the same type of cell adhesion. E-cadherin allele loss or decreased expression of hepatocellular carcinoma with invasion and metastasis. With normal liver tissue compared to liver cancer can be observed in E-cadherin mRNA and protein expression levels have fallen. Such cell invasion and metastatic properties of high can be transfected E-cadherin cDNA and the block, but also using anti-E-cadherin antibodies and reproduction of s