Advances in breast cancer related genes.docVIP

 PAGE \* MERGEFORMAT 9 Advances in breast cancer related genes [Keywords:] related genes of breast cancer Breast cancer is one of the most common malignancy of women, mainly in Europe and the United States, 70 from the 20th century, the formerly low-incidence area of breast cancer incidence increased year by year in Asia, especially in economically developed areas in China the incidence is also the rise in many cities, women’s breast cancer accounts for the first cause of death, and the rate of more than 3% annually. China every year, more than 40,000 women died of the disease [1], a serious threat of breast cancer of women’s health. complex etiology of breast cancer, and genetic factors, hormones, immune and environmental factors (chemical, biological factors, lifestyle and so on. But with the cell biology and molecular biology and technology, has recognized variant of breast cancer is a disease caused by multiple genes, the development of breast cancer associated gene abnormalities in awareness is the key to prevention and treatment of breast cancer. Many genes in different stages of development of breast cancer with different gene expression changes, these changes in gene expression affect the biological and clinical behavior of breast cancer. 1 c-erbB-2 (HER-2/neu) c-erbB-2 located on the long arm of chromosome 17 q11.2 ~ 12-bit, encoded 185kD transmembrane tyrosine kinase activity with growth factor receptor. in the c-erbB-2 gene activation studies showed that in primary of breast cancer, c-erbB-2 gene amplification rate is generally 20% to 30% [2]. on the c-erbB-2 and breast cancer research, the current mostly detected by immunohistochemical c-erbB- 2 expression in breast cancer cells, and most results showed that the expression in cancer cells was significantly higher than in normal tissue or cancer tissue, but the positive rate of coverage varies. Suli Ya [3] was detected using differential PCR 50 cases of breast cancer c-erbB-2 oncogene