Adiponectin and the relationship between kidney disease research progress.docVIP

 PAGE \* MERGEFORMAT 23 Adiponectin and the relationship between kidney disease research progress [Keywords:] adiponectin, primary glomerular disease, diabetic nephropathy, dialysis, literature review There is growing evidence that fat is not only a storage tissue, it is a functionally active endocrine organ, secreting a variety of forms through the release of adipokines such as leptin, resistin and adiponectin (ADPN.ADPN is ever found The only negative associated with obesity, fat cell specific protein, body mass index decreased the level of 21% and 46% ADPN. Recent studies also showed that, ADPN not only in the synthesis and secretion of fat cells, also expressed in bone marrow, femur and tibia osteoblasts, fetal tissue, myocardial cells and salivary gland epithelial cells. ADPN now on its role in kidney disease we reviewed. 1 Physical and Chemical Properties 1.1 gene Gene located on chromosome 3q27 ADPN, the total length of about 17 kb, whole genome scan showed that the chromosomal region is type 2 diabetes, metabolic syndrome susceptibility locus. Has been found that more than 10 genes common single nucleotide ADPN polymorphisms (SNPs and some rare missense mutations. studies suggest that the promoter region SNPs, exon 2 of the SNP +45, intron 2 and part of the SNP +276 missense mutation and type 2 diabetes and (or insulin resistance was correlated, this correlation is mainly due to mutations affecting the expression and function ADPN. 1.2 Structure and Function High levels of plasma ADPN adult body, about 3 ~ 30 g ml-1.ADPN by the 244 amino acids in the structure of collagen , , C1q homologue, the N terminal segment with 1 short signal peptide, followed by a a change in the height of the region, a collagen-like structure is in the carboxyl-terminal immunoglobulin-like structure of C1q, collagen-like sequence functions is to establish secondary and tertiary structure, spherical area function is to achieve the biological effect of ADPN