After application of alcohol induced by cefoperazone sulbactam Disulfiram-like reaction in 1 case of.docVIP

 PAGE \* MERGEFORMAT 5 After application of alcohol induced by cefoperazone sulbactam Disulfiram-like reaction in 1 case of [Keywords:] cefoperazone sulbactam alcohol disulfiram-like reaction Introduction 1 records Patients Moumou, male, 73 years old, because of abdominal pain, chest, face, skin flushing, chest tightness, lips cyanosis, limb weakness, difficulty in breathing 25min hospital. Were drinking liquor before 25 min after the burst of about 30g abdominal pain, chest tightness, hold breath, abdominal pain, nausea, no vomiting, admission BP 95/60 mmHg, P 108 times / min. electrocardiogram showed: sinus tachycardia. Jicha electrolyte show: K + 3.9 mmol / L, Ca2 +2.15 mmol / L. Diagnosis: acute gastritis. examination: BP 100/60 mmHg, P 110 times / min, clear consciousness, irritability, facial flushing, chest skin, conjunctival hyperemia, sweating, heart and lungs were normal. abdomen knocking drum sound, the left light tenderness , no rebound tenderness, decreased bowel sounds. ask medical history, patients with acute bronchitis in recent days to cefoperazone sulbactam, skin test negative, I 2g ivgtt bid/4d. The patient completed four days, 6 hours after infusion was after drinking a small amount of abdominal discomfort, choking not be attached to disable the disease after drinking the day of cefoperazone sulbactam. then amended diagnosis: Disulfiram-like reaction. immediate lying, low-flow oxygen, to the ground dexamethasone 5mg intravenous injection, intramuscular injection of promethazine hydrochloride 25mg, 5% glucose injection 500ml + Vitamin C 2g + Vitamin B6 0.2g intravenous infusion, the symptoms improved, decreased facial flushing, heart rate to 80 times / min, BP 120 / 70mmHg, no abdominal pain, emotional stability. 2 Discussion Disulfiram (disulfiram is a alcohol drug after taking the drug even if a small amount of alcohol consumed, the body can also cause serious discomfort, and achieve the purpose of drinking. When disulfiram