Aged diabetic insulin treatment options and safety comparison.docVIP

 PAGE \* MERGEFORMAT 7 Aged diabetic insulin treatment options and safety comparison Keywords: Intensive insulin therapy; elderly diabetic; glucose monitoring system Intensive insulin therapy is commonly used clinical method to control blood sugar, but the older diabetes blood sugar fluctuations, the high incidence of low blood sugar. The enhancement will lead to low blood sugar glucose. 1,2 domestic and international research shows that insulin analogues compared with ordinary insulin, can reduce the risk of hypoglycemia, but few reports on the application of senile diabetes. The experimental comparison of four methods of intensive insulin hypoglycemic, and application of glucose monitoring system (CGMS), we observed intensive insulin therapy in elderly diabetic patients 24 h after the change in blood sugar and low blood glucose spectrum. 1 Subjects and methods 1.1 Object 58 cases from January 2008 to July 2009 type 2 diabetic patient (T2DM) patients (fasting glucosegt; 8.0 mmol / L, 2 h after breakfast, blood glucosegt; 13 mmol / L), rule out serious infection, severe kidney disease and heart failure, type 1 diabetes, ketoacidosis and thyroid dysfunction. By diet, exercise and oral hypoglycemic drug therapy, blood glucose in patients is still not standard. Disease duration was 8 months to 15 years, age 65 to 85 years old. 1.2 Methods Selected diabetic patients on diet and exercise education, and disable any hypoglycemic drugs. Fasting plasma glucose (FPG) and glycosylated hemoglobin (HbAlc). Grouped according to blood glucose. The FPGgt; 9.5 mmol / L were randomly divided into 3 groups, A group of 15 patients received insulin pump therapy. B group 13 patients received short-acting insulin analogue plus long-acting insulin analogues. C group, 15 patients received in the ordinary effect of insulin plus insulin. And 8.0 mmol / L FPG lt;9.5 mmol / L in patients assigned to the D group, 15 patients received premixed insulin analogu