Application of echocardiography melatonin on the cardioprotective effects of diabetic rats.docVIP

 PAGE \* MERGEFORMAT 14 Application of echocardiography melatonin on the cardioprotective effects of diabetic rats Of: Wang Jianfei, Fang Chun Qian, Chen Kui, Gao Jing, Zhang Guohui [Abstract] Objective: To observe the melatonin (MT of streptozotocin (STZ-induced diabetic rat heart protective effects of echocardiography in early diagnosis of diabetic cardiomyopathy. Methods: STZ-induced diabetic rat model , will become the model of diabetes in diabetic rats were randomly divided into intervention group and the melatonin group and normal group as control. MT 8 weeks later, blood glucose, blood pressure, oxidation index malondialdehyde (MDA, indicator of antioxidant superoxide dismutase (SOD, echocardiography rats changes in cardiac structure and function, HE staining of myocardial tissue. Results: Compared with normal group, diabetes, blood pressure levels, MDA content increased (P lt;0.05, SOD levels decreased ( P lt;0.05, diastolic and systolic function decreased (P lt;0.05, compared with the diabetic group, MDA content of melatonin treatment group decreased (P lt;0.05, SOD levels increased (P lt;0.05, systolic function improved (P lt;0.05, diastolic function continued to deteriorate, the situation has improved pathology. Conclusion: MT system can regulate the balance between oxidation and antioxidation, the heart of diabetic rats has a protective effect, echocardiography can be used for observation of cardiac structure and function of the change, which early diagnosis of diabetic cardiomyopathy. [Keywords:] echocardiography, melatonin, diabetes, heart [Abstract] Objective: To observe the effect of melatonin (MT) on streptozotocin (STZ) induced diabetic rat heart and the early diagnosis value of echocardiography in diabetic cardiomyopathy.Methods: STZ induced diabetic rats were randomly divided into diabetic group and MT intervention group (intervention with MT for 8 weeks), and the normal group as control. The blood pressure, blood glucose levels,