Application of heparin-coated cardiopulmonary bypass pipeline progress.docVIP

 PAGE \* MERGEFORMAT 6 Application of heparin-coated cardiopulmonary bypass pipeline progress [Keywords:] Summary of CPB heparin-coated pipes The best blood compatibility than the surface of vascular endothelial cells. Studies have shown that microvascular endothelial cell surface The existence of heparin-like molecules and other bioactive substances to prevent local thrombosis. As can heparin-binding in the The surface of artificial material, it is possible to simulate the human body with artificial material part of the vascular endothelial function, to avoid the formation of thrombus To increase the biocompatibility of artificial materials. 1963, Gott et al [1] the first time, plasma heparin binding way Combined with synthetic materials to increase the anti-thrombotic properties of artificial blood vessels. After it was discovered that heparin coating materials may have Efficiency to improve biocompatibility of polymeric materials, thereby reducing postoperative systemic inflammatory response. A heparin-coated materials, principles and structure 1.1 The combined approach is the use of heparin plasma itself contains a large number of negative charge, with cationic surfactant Or contain cationic polymer coated on the surface, through the charge to adsorption of heparin molecules. Currently on the market DurafloII surface (BaxterHealthcareCorp, BentleyLaboratoriesDivition, Irvine, Calif.) That is ion-binding mode. 1.2 covalent binding is through a special covalent binding to heparin molecules on the surface. The use of carbon Of two imine to heparin connected to the hydrolysis of poly methyl methacrylate; heparin and through covalent bonding of glutaraldehyde On the PVA. Covalent bonding requires special chemical reactions to heparin-binding to the polymer surface. Right CPB supplies, each part of the material on the surface need to be independently heparin-coated. This approach allows the heparin Activity decreased gradually wit