Ascorbic acid organic germanium sesquioxide inhibit angiogenesis in chick chorioallantoic membrane in vitro.docVIP

 PAGE \* MERGEFORMAT 9 Ascorbic acid organic germanium sesquioxide inhibit angiogenesis in chick chorioallantoic membrane in vitro Author: Chen Fang Yan Jing Guo Qing ZHANG Ji-Jia Guizhi cold autumn [Abstract] Objective To study the ascorbic acid organic germanium sesquioxide right chick chorioallantoic membrane (CAM) angiogenesis in vivo. Method on the 7th age of CAM implanted with different doses of the drug test methyl cellulose membrane, and incubating 48 h. Counted under the dissecting microscope dosing group and the control group, the number of local blood vessels as a way to reflect the test drugs on the impact of CAM neovascularization. The results of ascorbic acid organic germanium sesquioxide 2.5,1.5,0.5 mg / egg dose-dependent reduction in the number of CAM blood vessels locally. Conclusion ascorbic acid organic germanium sesquioxide on CAM angiogenesis inhibition significantly. [Keywords:] ascorbic acid organic germanium sesquioxide chick chorioallantoic membrane (CAM) anti-angiogenesis Abstract: ObjectiveTo investigate the antiangiogenesis effect of the ascorbic Acid SesquioxyGe (Ⅳ ) on chicken embryo chorioallantoic membrane (CAM). MethodsThe ascorbic acid SesquioxyGe (Ⅳ ) loaded with methylcellulose membranes was applied on chicken CAM surface of 7-day-old eggs and incubated for 48 hours. Local vessel density was measured under dissection microscope. The inhibitory effect on CAM angiogenesis was evaluated.ResultsThe Ge (Ⅳ ) complex with ascorbic acid at 2.5,1.5 mg / egg and 0.5 mg / egg dose-dependently decreased the density of local blood vessels. ConclusionAscorbic acid SesquioxyGe (Ⅳ ) significantly inhibits chicken CAM angiogenesis. Keywords:: Ascorbic Acid SesquioxyGe (Ⅳ ); Chicken embryo chorioallantoic membrane (CAM); Antiangiogenesis Tumor growth and metastasis and is closely related to the formation of new blood vessels. Clinical and animal experiments demonstrated that when the tumor tissue growth Chao Guo 2 mm3, if there is no ne