B crystallin protein profile in the lens outside of.docVIP

 PAGE \* MERGEFORMAT 16 B crystallin protein profile in the lens outside of Of: a wax Wang, Hou Shi-Ke, Jyh-Horng Wu [Abstract] @ B is the vertebrate eye lens protein in the lens of one of the major protein component in the body are widely expressed in various tissues, it is the small heat shock protein family member, with the molecular chaperone activity, can inhibit a variety of environmental changes of apoptosis, while the development of some tumors and tumor resistance to treatment are closely related, the authors of this research in recent years are reviewed. [Keywords:] @ B crystallin protein; heat shock protein; cell protection; tumor drug resistance; Literature Review @ B crystallin lens protein is the major structural components. In recent years, @ B crystallin protein in the lens have been outside the organization (such as brain, heart, stomach, lung, kidney, muscle and retina, etc.) to create awareness of the discovery of , @ B crystallin protein in the lens is not only a structural component, may also have important functional significance. We are all familiar with @ B crystallin protein in the lens of the role, but in recent years found @ B crystallin protein in the lens also played outside biological effects. 1 @ B crystallin protein coding genes, expression and structure of parts @ B crystallin in the vertebrate eye lens protein component of the main, is the lens protein @ @ B, one of the two genes encoding gene product contains 175 amino acids. @ B gene is located on chromosome 11, which, @ A lens protein genes from an ancient @ crystallin gene, this gene in the software branch of the fish and the evolution of higher vertebrates has been there before, and its transcripts play a small heat shock protein (heat shock protein, HSP) of the function and the body of vertebrates today @ B as the functions of lens proteins. @ B crystallin protein was mainly expressed in the mammalian lens, which lens proteins with @ A molar ratio of