Brain natriuretic peptide and cardiopulmonary bypass heart surgery.docVIP

 PAGE \* MERGEFORMAT 14 Brain natriuretic peptide and cardiopulmonary bypass heart surgery [Keywords:] brain natriuretic peptide during cardiopulmonary bypass heart surgery In recent years, brain natriuretic peptide in the diagnosis of congestive heart failure, myocardial infarction and left ventricular dysfunction to the important effect which has led people to pay attention [1-2], cardiopulmonary bypass (extracorporeal circulation, ECC) Perioperative cardiac surgery Brain variation of natriuretic peptides may also have the same role in the diagnosis and prognosis. This paper will brain natriuretic peptide and cardiac surgery, the relationship between the ECC reviewed. 1 Background Circulating natriuretic peptide family (NPs) by the atrial natriuretic peptide (atrial natriuretic peptide, ANP), brain natriuretic peptide (brain natriuretic peptide, BNP), C2-type natriuretic peptide (C2-type natriuretic peptide, CNP) [3] and the newly discovered DNP (Dendroaspis natriuretic peptide) [4] form. According to study at home and abroad, ANP and BNP were secreted mainly by the atrium and ventricle, as a circulating cardiac hormones play a diuretic, natriuretic, and relaxation of smooth muscles such as the role of blood pressure, regulate body fluid environment; CNP is mainly produced by vascular endothelial cells, physiological, role is to expand blood vessels, the local regulation of vascular pressure; DNP present in human and dog plasma, atrial muscle [4]. BNP is also known as brain natriuretic peptide, because in 1988 by Sudoh et al [5] first purified from porcine brain and named, mainly secreted by the ventricles, especially careful when the chamber pressure increased secretion, increase the extent and ventricular dilatation and pressure overload is proportional to, so you can accurately reflect the changes in ventricular function, ventricular dysfunction is a high-specific, highly sensitive biomarkers. 1.1 BNP structure and expression of BNP is a 32 amino ac