Breast cancer tissues PCNA cerbB2 p53 ER PR gene expression.docVIP

 PAGE \* MERGEFORMAT 16 Breast cancer tissues PCNA cerbB2 p53 ER PR gene expression Of: Jia Zongliang, Linzi Jing, Xiang-Ming, Yao Lu [Abstract] Objective To detect breast cancer tissue by proliferating cell nuclear antigen (proliferating cell nuclear antigen, PCNA), C erbB 2, p53, estrogen receptor (estrogen receptor, ER) ?p progesterone receptor (progesterone receptor, PR ) protein expression, of Chinese women breast-conserving surgery for the safety of resection. Methods 40 cases of radical mastectomy in patients with resected specimens, each specimen will be divided into the tumor area and adjacent areas, further subdivided into adjacent areas adjacent 1cm, 2cm, 3cm andgt; 3cm group. immunohistochemistry SP method detected in the breast tissue more than 5 groups, the incidence of atypical hyperplasia and PCNA, c erbB 2, p53, ER, PR protein expression differences. Results farther away from the primary tumor, adjacent tissue dysplasia and c erbB 2, p53 protein, the lower the ratio of positive (P lt;0.05), adjacent 1cm, 2cm group of risk factors (atypical hyperplasia, and c erbB 2, p53) ratio was significantly higher than 3cm group (P lt;0.05), while the adjacent 1cm and 2cm was no significant difference between groups (Pgt; 0.05), PCNA, ER, PR in adjacent tissues and differentiation, no significant relationship between lymph node metastasis (Pgt; 0.05). Conclusion breast conserving surgery is recommended as a safe 2cm adjacent to cancer resection. [Keywords:] breast conserving surgery, atypical hyperplasia, proliferating cell nuclear antigen, c erbB 2, p53, estrogen receptor, progesterone receptor ABSTRACT: Objective To detect the expressions of proliferating cell nuclear antigen (PCNA) , C erbB 2, p53, estrogen receptor (ER) and progesterone receptor (PR) in order to explore the proper margin for breast conservative surgery on Chinese women. Methods We collected 40 resection specimens from breast cancer patients who had received radical surgery. The