Chifeng City the first case of autologous stem cell transplantation in the treatment of small cell lung cancer.docVIP

 PAGE \* MERGEFORMAT 5 Chifeng City the first case of autologous stem cell transplantation in the treatment of small cell lung cancer [Keywords:] Lung Cancer Small cell lung cancer (sCLC) is a highly malignant tumor, the early emergence of regional lymph node and distant metastasis. So as the main clinical treatment with chemotherapy [1]. The disease sensitive to chemotherapy, the effective rate of single-agent clinical common joint programs. this case with autologous hematopoietic stem cell transplantation (aSCT) treatment to obtain a good effect, are as follows. 1 Materials and methods 1.1 Clinical data of patients, female, aged 58, and August 21, 2006 was admitted to hospital after a CT showed right lung occupying, pathological diagnosis after the deadline for the sCLC Bureau. 1.2 aSCT mobilization, collection, preservation and reinfusion 1.2.1 aSCT mobilization using high-dose chemotherapy and mobilization of mobilization. Option: paclitaxel (135mg/m2 + carboplatin (AUC = 5) + VP-16 (75mg/m2), day 1 to 3 days, four cycles (10 days per cycle achieved complete remission, given mobilization of recombinant human granulocyte colony stimulating factor rhG-CSF (Kirin Products) 5 ~ 10g/kg subcutaneous injection of 5 to 10 days [2]. 1.2.2 aSCT collection, preservation and transfusion when the peripheral WBCgt; 1.0 109 ~ 5.0 109 / L, PLTgt; 20 109 ~ 50 109 / L, peripheral blood CD34 (+) cellsgt; 1%, began collecting . using the CS-3000plus cell separator (Baxter produced the United States. separate folder with GRANULO, collection of folders with the A-35, full blood flow velocity 55mL/min, whole blood: anticoagulant is 10:1, the end value 10 000mL ( required to determine, 1 000mL saline, 500mL anticoagulant (ACD-A, 600mL transfusion bags, and a pipeline of consumables. according to the procedure for the collection. aSCT 200mL collected at 4 refrigerator, to be pretreated 72 hours after the intravenous transfusion. 1.3 The basic scheme for